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Observe Intently (one)pentobarbital will lower the extent or result of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to your reduce in fentanyl plasma concentrations, insufficient efficacy or, possibly, enhancement of